Methyltransferases in Biocatalysis

Ludger Wessjohann, Martin Dippe, Martin Tengg, and Mandana Cruber-Khadjawi 

To impose specific properties, natural methylation has to be selective, that is, in most cases chemo- and regioselective, more rarely diastereo- and enantioselective. 

Cascade Biocatalysis Integrating Stereoselective and Environmentally Friendly Reactions, First Edition. 

Edited by Sergio Riva and Wolf-Dieter Fessner. 

This is achieved by methyltransferases (MTs), which almost exclusively use S-adenosyl-L-methionine (SAM) as cofactor. 

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