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2-Methylthiopyrazine

Methylthio-2-pyrazinecarbaldehyde (163, X = O) and the Witting reagent, (ethoxycarbonylmethylene)triphenylphosphorane, gave 2-(2-ethoxycar-bonylvinyl)-3-methylthiopyrazine (163, R = CH2C02Et) (neat reactants, N2, 135°C, 8 h 87%).1126... [Pg.103]

Methyl-3-methylthiopyrazine (249) gave 3-methylthio-2-pyrazinecarbalde-hyde (250) (Se02, dioxane, reflux, 4 h 62%).1126... [Pg.117]

Chloro-3-methylpyrazine (154, R = Cl) gave 2-methyl-3-methylthiopyrazine (154, R = SMe) MeSNa, EtOH, 20°C reflux, 2 h 92%), 2-ethoxycar-bonylmethylthio-3-methylpyrazine (154, R = SCH2C02Et) [NaSCH2C02Et (made in situ), likewise 91%), or analogues.1126... [Pg.167]

Benzoyl-3-methylthiopyrazine gave 2-benzoyl-3-methylsulfonylpyrazine (57) [Oxone (2 KHS05.KHS04.K2S04 complex 2 mol), H20—MeOH, 20°C, 3 days 75%].1564... [Pg.254]

Methyl-3-methylthio-2-pyrazinamine 2-Methyl-3-methylthiopyrazine 2-Methyl-5-methylthiopyrazine 2-Methyl-6-methylthiopyrazine Methyl 3-nitro-2-pyrazinecarboxylate... [Pg.446]

The methylsulfonyl substituent was readily displaced from pyrazine. Thus 2-methylsulfonylpyrazine (7) with methoxide ion at 87° for 3 hours gave 2-methoxy-pyrazine (1079), and 2-methylsulfinylpyrazine displayed similar reactivity, but 2-methylthiopyrazine was less reactive (1080). [Pg.170]

Kinetics have been determined for the displacement of the methylthio group from 2-methylthiopyrazine by methoxide ion. At 129.9° the rate coefficient was 2.83 X 10" 1/mol sec, energy of activation 24.6kcal/mol, and logyl 10.76 (1080). The reaction was bimolecular but the methoxide ion concentration remained constant throughout the reaction owing to its regeneration from the oxidation of the methanethiol produced (1080). [Pg.199]

Methylthiopyrazine reacts with methoxide ion at elevated temperatures to give 2-methoxypyrazine, and the kinetics have been determined (Section 3) (1080). Anhydro-2,6-dihydroxy-l,4-diphenyl-3,5-bis(phenylthio)pyrazinium dihydroxide, for example, (14), with a saturated solution of hydrogen chloride in acetic acid at room temperature gave 2,3-dioxo-l,4-diphenyl-5-phenylthio-l,2,3,4-tetrahydro-pyrazine (6.4%) (15) and l,4-diphenyl-6-phenylthiopiperazine-2,3,5-trione (60%) (476a). [Pg.201]

See other pages where 2-Methylthiopyrazine is mentioned: [Pg.226]    [Pg.162]    [Pg.180]    [Pg.775]    [Pg.121]    [Pg.368]    [Pg.378]    [Pg.384]    [Pg.384]    [Pg.384]    [Pg.384]    [Pg.393]    [Pg.433]    [Pg.450]    [Pg.459]    [Pg.459]    [Pg.459]    [Pg.162]    [Pg.197]    [Pg.199]    [Pg.200]    [Pg.201]    [Pg.201]    [Pg.203]    [Pg.203]    [Pg.219]    [Pg.313]    [Pg.162]    [Pg.180]   
See also in sourсe #XX -- [ Pg.219 ]



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2- Methyl-3-methylthiopyrazine

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