3- Methylpyridine-l -oxide

Methylpyridine-l-oxide (3-picoline-l-oxide) may be prepared by a method similar to that employed for pyridine-1-oxide. To a mixture of 600-610 ml. of glacial acetic acid and... 

Methylpyridine-l-oxide has been prepared by the oxidation of 3-methylpyridine with hydrogen peroxide in glacial acetic acid, with 40% peracetic acid and sodium acetate, and with per benzoic acid in benzene. ... 

Methyl-4-nitropyridine-l-oxide has been prepared by the nitration of 3-methylpyridine-l-oxide hydrochloride with a mixture of concentrated sulfuric acid and potassium nitrate. The I)reparation of this compound has been mentioned briefly by Talikowa, but no experimental details have been given. 

Preparation of substituted pyridinecarboxyUc acid 1-oxides by means of H-abstraction is reported by Abramovitch and others. Thus, treatment of the lithium derivative of 4-chloropyridine-l-oxide or 4-chloro-3-methylpyridine-l-oxide with CO2 gave the corresponding 4-chloro- and 4-chloro-5-methylpicolinic acid-1-oxides. Under the same conditions, 4-picoline-l-oxide gave the 2,6-di-carboxylic acid. 

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