2-Methylpropanoyl chloride

Reports by Mattocks397,398 that 2-acetoxy-2-methylbutanoyl chloride reacts with 1,2- and 1,3-diols to afford chloroacetates led to an investigation into use of this type of reagent for selective transformation of the vicinal diol grouping in ribonucleosides. Greenberg and Mof-fatt399 chose to use 2-acetoxy-2-methylpropanoyl chloride (which lacks the complication of a chiral center), and, firstly, found that cis-... 

The reaction of adenosine with 2-acetoxy-2-methylpropanoyl chloride or the corresponding bromide is less regioselective than that of uridine,400 and gives 9-(2-0-acetyl-3-deoxy-3-halo-/3-D-xylofuranosyl)-and9-(3-0 - acetyl - 2 - deoxy - 2 - halo - /3 - D - arabinofuranosyl) - adenine,... 

Methylpropanoyl chloride Isobutyryl chloride (8) Propanyl chloride, 2-methyl- (9) (79-30-1)... 

Acylation reactions of l-aryltetrazol-5-ones generally occur on the N(4)-position, but acylation of the exocyclic oxygen atom occurred in up to 50% yield when the acylating agent was 2-methylpropanoyl chloride (73ZC429). Fragmentation and rearrangement reactions of 5-alkoxytetrazoles are discussed in Section 4.13.3.2 and alkylations of these systems in Section 4.13.3.5. 

---