Methylene bisfluoroacetate

Chloromethyl esters are obtained quite readily by the action of paraformaldehyde on the appropriate acid chloride in the presence of a small quantity of zinc chloride as catalyst.1 It therefore seemed worth while to try the action of paraformaldehyde on fluoroacetyl fluoride, but the only product which could be isolated was a low-melting solid which appeared from its reactions to be methylene bisfluoroacetate, CH2(0 CO CH2F)2. The compound was submitted for physiological tests, and it was shown that the l.d. 50 subcutaneous injection into mice was about 10 mg./kg. Subcutaneous injection into rats with doses of 2-5, 5 and 10 mg./kg. all killed 1/1. 

---

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

---