Methylcyclohexane, ring inversion

Ring inversion in methylcyclohexane differs from that of cyclohexane m that the two chair conformations are not equivalent In one chair the methyl group is axial m the other It IS equatorial At room temperature approximately 95% of the molecules of methylcyclohexane are m the chair conformation that has an equatorial methyl group whereas only 5% of the molecules have an axial methyl group... 

Substitution on a cyclohexane ring does not greatly affect the rate of conformational inversion but does change the equilibrium distribution between alternative chair forms. All substituents that are axial in one chair conformation become equatorial on ring inversion, and vice versa. For methylcyclohexane, AG for the equilibrium... 

One after the other, step through (or animate) the sequence of structures depicting ring inversion in cyclohexane, methylcyclohexane and trans-l,2-dimethylcyclohexane. Is the overall motion involved in the ring inversion similar in all three Describe any differences. 

Ring inversion of methylcyclohexane, which exchanges equatorial and axial methyl groups at room temperature, is frozen at 100 °C [213]. In this situation, the methyl and... 

The most stable form of a monosubstituted cyclohexane is, like cyclohexane itself, a chair conformation. There are, however, two valid chair conformations and again, like cyclohexane, these are interconvertible by ring inversion. In the particular case of methylcyclohexane, they are shown by 22 and 23. 

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