Methylation silver oxide assisted

Nucleophilic dithioacetalisation can be used to introduce acyclic dithioacetals adjacent to carbonyls too. For example the lithium enolate of ester 96.1 was converted to the dithioacetal 96.2 in good yield using methyl methanethiosulfo-nate [Scheme 2.96].191 After elaboration of the chain, the carbonyl group was deprotected by silver(I)-assisted oxidative hydrolysis. 

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