Pyridine methyl-substituted

Good yields of fluoro-substituted aromatics have been obtained when 1 -chloro-2,4-dinitrobenzene (10) and 1-chloro-2,6-dinitrobenzene (13) are first treated with pyridine or methyl-substituted pyridines to form intermediate salts 11 and 14 and then reacted with potassium fluoride in dimethylformamide or nitrobenzene to give the fluorides 12 and 15."°... 

This method could successfully be extended to the conversion of methyl-substituted pyridines into (trifluoromethyl)-substituted pyridines.23,24... 

The corrosion inhibiting properties of an organic molecule may be modified by structural changes that alter the availability of electrons. A good correlation has been observed between the relative corrosion inhibiting ability of certain methyl-substituted pyridines and Hammett-like substituent constants (65MI11501). 

Apart from methyl-substituted pyridines, p-tolyl- and 4-methyl-styrylpyridines have also been found to react with benzalaniline. Thus, 2,6-diphenyl-4-(p-tolyl)pyridine (188) gives the stilbenyl derivative 189, and the stilbazole 190 gives 4-[/3-(3-pyridyl)vinyl]stilbene (191) (Table XIX).34... 

Manchanda, V.K. Subramanian, M.S. Infrared and P.M.R. investigations of some complexes of uranyl beta diketonates with methyl substituted pyridine N-oxides, Aust. J. Chem. 27 (1974) 1573-1577. 

Copper (II) /i-diketonates form 1 1 adducts with heterocyclic bases. With pyridine derivatives, there is a Bronsted plot between the log of the stability constant and the pKa (Scheme 31). The 2-methyl-substituted pyridines are on a parallel line and 2,6-dimethylpyridine falls below the line (78BCJ805). The picture is very similar to what is observed in quaternization of pyridines (83T4209). 

ZD0473 (formerly AMD473, JM473) was developed in order to overcome acquired or intrinsic (de novo) resistance to cisplatin. Based on the steric bnlk of its methyl-substituted pyridine moiety, thiol snbstitntion and drug inactivation is hindered compared with cisplatin. In several in-vitro studies, ZD0473 was active even in cisplatin-refractory tumor cells, whose key mechanism of resistance was based on thiol substitution. In addition, ZD0473 is also active in cisplatin-resistant tumor cells, in which resistance is based on altered drug transport mechanisms or enhanced DNA repair. 

Substitution reactions of cis-Ru(bipy)2X2 (X = F, Cl, or Br) with methyl-substituted pyridines have been studied in various non-aqueous solvents and the results indicate a dissociative mechanism via [Ru(bipy)2X] as the intermediate. The outer-sphere electron transfer between [Ru(NH3)g] and [(NH3)5Co02Co(NH3)s] has been monitored. Flash photolysis at the intense metal-to-ligand CT band (508 nm) of the pyrazine complex [(NH3)5Ru"(pyr)Cu"] causes an intramolecular electron transfer to [(NH3)5Ru (pyr)Cu ]. This allowed the unimolecular reverse electron-transfer process to be monitored. 

The extractant 4-(5-nonyl)pyridine in benzene displays considerable advantage over pyridine and methyl-substituted pyridines in that its solubility in water is almost negligible. However, the distribution coefficients proved to be rather low. 

Thome, F.A. Qualitative determination of methyl substituted pyridines added to smoking tobacco RDM, 1970, 3916a. 

Pt -Pt jU-0,0 -bridged hydrogen phosphate complexes (NH4)2[ 2(lw-HP04)4(H20)2] can be prepared along with the complexes where the axial water molecules are replaced 1 halide, NH3, pyridine and methyl-substituted pyridines. Where structural data have been collected, the Pt-Pt distances fall in the 2.45-2.50 A range. 

Methyl substituted pyridines such as 2,6-lutidine and 2,4,6-collidine can also afford undesirable by-products. These pyridines can react with Tf20 to generate sulfinate- and trifluoromethyl-substituted derivatives (eq 46). In such cases, the use of 2,6-di-... 

Hydrogen bonding in methyl-substituted pyridine-water complexes A theoretical... 

In a study of methyl-substituted pyridines, the aryl regions of the overtones show a simplified structure having one peak progression for each nonequivalent C-H. The methyl regions of the methylpyridines show complex profiles. The band profile in 3- and 4-methylpyridine is similar to that of toluene because the methyl groups of these compounds are free rotors, and all have a low-energy barrier to rotation. However, the methyl band profiles of 2-methylpyridine are complex, and these patterns indicate that vibration-torsional coupling is an important contribntor to the complex structure." ... 

Proos, R.J. and Henry, B.R., Overtone investigation of methyl-substituted pyridines, J. Phys. Chem. A, 103, 8762-8771, 1999. 

Papai, L, Jancso, G. (2000), Hydrogen bonding in methyl-substituted pyridine-water complexes A theoretical Journal of Physical Chemistry A, 104, 2132-7. 

Table III refer to the many derivatives and isomers observed, e.g. methyl-substituted pyridines or bipyridines. An example of these is indicated in Figure 3 for TMPyPCl pyrolyzed at 600°C. For this particular sample, two small peaks of m/e 249 are observed but are as yet not assigned, although they may be due to isomers of tripyridines. A small amount of pyrrole is also seen at this temperature (but not at 420 C, and therefore cannot be attributed to impurity), indicating a slight degree of decomposition of the porphyrin core.

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