Methyl 2-Pyrrolyl Ketone

Methyl 2-Pyrrolyl Ketone, 64 Methyl Sulfide, 70 4-Methyl-5-thiazole Ethanol, 84... 

Geranyl butyrate 225 Isoamyl butyrate 273 Methyl 2-pyrrolyl ketone... 

Synonyms Methyl 2-pyrrolyl ketone 1-(1H-Pyrrol-2-yl) ethanone... 

Methyl 2-pyrrolyl ketone. See 2-Acetyl pyrrole 2-Methylquinoline. SeeQuinaldine 4-Methylquinoline. SeeLepidine a-Methylquinoline. SeeQuinaldine y-Methylquinoline p-Methylquinoline. See Lepidine... 

New calix[4]pyrroles 145 bearing dipyrrolylquinoxaline as strapping elements have been synthesized (Kim et al. 2009). The synthesis of receptor 145 starts with ketone 142, a species that was prepared by the reaction of oxalyl chloride with 2 equivalents of 2-(3-oxobutyl)pyrrole (Yadav et al. 2001). Once in hand, 142 was reacted with 4-nitro-1,2-DAB in the presence of acid to afford bisketone 143 in 24 % yield (Black et al. 1999 Anzenbacher et al. 2000). Treatment of this latter intermediate with neat pyrrole in the presence of trilluoroacelic acid afforded the bis-dipyrromethane 144 in 74 % yield (Scheme 5.34). While this procedure proved effective, attempts to effect the direct alkylation of 6-nitro-2,3-di(2 -pyrrolyl)qui-noxaline with methyl vinyl ketone produced only trace quantities of the desired product 144. Acid-catalyzed condensation of 144 with acetone then gave the... 

DIPHENYLHYDROXYMETHYL)PIPERIDINO lODOMETHYL see IDZ200 KETONE, DI-1H-2-PYRROLYL see PPY300 KETONE, 2-ETHYL-7-(2-HYDROXY-3-(ISOPROPYI-.3MINO)PROPOXY)-4-BENZOFURANYL METHYL see ELI600... 

As in the example shown below, the Vilsmeier-Haack reaction was performed on 2-benzoyl-1-methyl-lf/-pyrrole to afford the C2 formylation product in 44% yield and the C3 ketone affords the C2 formylation product in 44% yield in 56% yield The two pyrrolyl aldehydes, in turn, were converted into the corresponding hydroxamates, which are a new class of histone deacetylase (HDAC) inhibitors. 

A soln. of 2-(5-phenyl-2-pyrrolyl)ethyl methylsulfinyl(phenylcarbamoyl)methyl ketone and p-toluenesulfonic acid monohydrate in isopropanol refluxed 1 hr. 

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