6-Methyl-477-pyrido pyrimidin-4-ones nitration

Hydroxy-2-methyl-4//-pyrido[ 1,2-a]pyrimidin-4-one 365 gave 8-sub-stituted derivatives in a reaction with different electrophilic reagents (Scheme 28) (92KGS1660). Nitration gave 8-nitro-9-hydroxy-2-methyl-pyridopyrimidin-4-one 326. Reaction with iodine afforded 8-iodo-... 

Nitro-6-methyl-4//-pyrido[l,2-a]pyrimidin-4-one was prepared from 6-methyl-4//-pyrido[l,2-a]pyrimidin-4-one by nitration with a mixture of concentrated nitric and sulfuric acids at ambient temperature for 2 hours (85JHC481). 

Nitration of 2-(l-piperazinyl)-4 -pyrido[l, 2-a]pyrimidin-4-one with 99% HNO3 in 96% H2SO4 at 0°C (00BMC751) and that of 2-methyl-4 -pyrido[l,2- z]pyrimidin-4-one and its 6-, 7-, 8-, and 9-methyl... 

---