1 «Methyl-2-phenyl-4-quinolone

Hydroxy-1 -methyl-2-phenyl-4-quinolone 312 c,6h,3no2 174-175 Lunasia quercifolia Lauterb and K. Schum 69... 

C10H8O2 methyl 3-phenyl-2-propynoate 4891-38-7 571.40 50.785 2 18910 C10H9NO2 4-hydroxy-1 -methyl-2-quinolone 1677-46-9 590.98 52.691 2... 

A nucleogenic phenyl cation has been generated by -decay of tritium-labeled benzene and reacted with methyl-substituted quinolones. A double tritium-labeled benzene (216) was prepared from 1,4-dibromobenzene. Decay of a tritium leads to the phenyl cation (217) and this cation reacts with 8-methylquinoline to give products (218) and (219). 

Atkinson and co-workers treated p-chlorophenyl 2-butenyl sulfide with 1,2-dihydro-2-quinolon-l-ylnitrene, and found two isomers in the product 76, between which equilibrium was reached by heating at 100°C for 30 min (121). The barrier was later determined to be 26.1 kcal/mol (122). A similar phenomenon was observed for the product obtained when 3-methyl-2-butenyl phenyl sulfide was used. However, the product (77) from /V-phthalimidonitrene afforded... 

Methoxy-l-methyl-2-phenyl-4-quinolone (XXVIII) C17H15NO2 198-200 0 12... 

Sulfonylmethylene compounds such as methyl sulfonylacetate (220 R2 = Me, R3 = OEt) or phenyl phenacyl sulfone (220 R2 = R3 = Ph) give with N-substituted IA the corresponding 4-hydroxy-3-sulfonyl-2-quinolones... 

Hydroxy-l-methyl-2-phenyl-4-quinolone (3), obtained previously from Lunasia quercifolia, now has been isolated from Skimmia japonica. Details have been published of the Italian synthesis of halfordamine (6) (see Vol. 4 and Vol. 5 of these Reports) and related 2-quinolones. ... 

Hydroxy-l-methyl-3-phenyl-2-quinolone (56) is formed with a yield of 80% as a result of the reaction of the anhydride 2 with ethyl phenylacetate in the presence of potassium bis(trimethylsilyl)amide at -78°C [34],... 

Budzisz et al. have described the synthesis and the antimicrobial properties of chromone derivatives (01APPMC381). These compounds were synthesized and tested for their antimicrobial activity against Gram-positive and Gramnegative bacteria using naHdixic acid as reference. (NaHdixic acid is one the first synthetic quinolone antibiotic.) The first cycHc phosphonic analogs of chromone 139 were obtained by the reaction of dimethyl 2-methyl- and dimethyl 2-phenyl-4-oxo-4H-chromen-3-ylphosphonate 138 with primary amines (99T4815) (Scheme 31). 

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