2-Methyl-1-nitro-2-nitroso

Methyl-/ /-nitro-/ /-nitroso- quanidine C2H5N503 70-25-7 147.093 sDMSO... 

NITRO-, DIACETATE, 36, 58 -Toluenesulfenyl CHLORIDE, 35, 99 -ToLUENESULFINYL CHLORIDE, 34, 93 -Toluenesulfonamide, N-methyl-N-nitroso-, 34, 24, 96 -Tolucnesulfonic acid, 30, 30, 31 monohydrate, 36, 92 -ToLUENESULFONIC ANHYDRIDE, 36, 91 -Toluenesulfonylanthranilic acid, 32, 8, 11... 

A comparison of structures of V-methyl-V-nitroso-p-nitrobenzamide, N,N -dimethyl-V-nitrosourea, V-methyl-V-nitrosourea, 2-nitroso-2-azabicyclo[2.2.2]octan-3-one to those of V-methyl-V -nitro-V-nitrosoguanidine and V,V -dimethyl-V"-cyano-V-nitrosoguanidine shows that the N—N and C—NNO bond lengths in the nitroguanidines44 are similar to those found in the nitrosoamides, but that the corresponding bonds in... 

Diazomethane (called Diazomethan in Ger), C cNiN mw 42.04, N 66.64% poisonous yel gas condensing to a yel liq, bp -24 to -23° and solidifying in pale-yel crysts, fr p -145° explodes violently when heated to a higher temp sol in eth more important methods of prepn are from nitrosomethylurea, nitroso-methylurethane, a mixt of chloroform fit hydrazine hydrate, or l-methyl-l-nitroso-3-nitro-guanidine by reaction with KOH from nitrosyl chloride methylamine by treatment of the Na salt of formaldehyde oxime with chloramine and by other methods... 

Major sources are the basic hydrolysis of V-methyl-V-nitrosourea (or V-methyl-V-nitroso-/)-toluenesulfonamide (Diazald ) or l-methyl-3-nitro-l-nitrosoguanidine (MNNG). 

Protected amino acids or peptides are activated at the carboxy group by the mixed anhydride method using isobutyl chloroformate and NMM and reacted with ethereal diazomethane to form the corresponding peptidyl diazomethyl ketone (Scheme 1). The diazomethane solution is prepared from TV-methyl-A -nitroso-d-toluenesulfonamide (Diazald, Aldrich) or l-methyl-3-nitro-l-nitrosoguanidine (MNNG, Aldrich) according to the supplier s instruction (Aldrich information bulletin No. Al-180). No racemization occurs when diazomethyl ketones are prepared by this method. 

Pd-catalyzed coupling reactions at the 5-position of 6-phenyl-3(2W)-pyridazinones using a retro-ene transformation have been reported <02SL2062>, and the Pd-catalyzed arylation of 4-bromo-6-chloro-3-phenylpyridazine has been shown to be efficient and regioselective <02SL223>. The N-methylation of substituted 3(2//)-pyridazinones with Ai,iV-dimethylformamide dimethylacetal has been explored <02SC1675>, as have the preparation of 3-nitro-, -nitroso- and -chloro-derivatives of... 

Cyclohexadien 5-lsopropyl-2-methyl-3-nitro- V/lc, 163 Cyclohexan 1-lsopropenyl-4-methyl-4-nitroso-3-oxo- (dimer) X/l, 906f. 

SYNS AMN METHYLAMYLNITROSAMN (GERMAN) METHYLAMYLNITROSAMINE METH-YL-N-AMYLNITROSAMINE N-METHYL-N-NITROSO-PENTYLAMINE METHYL-N-PENTYL-NITROSAMINE N-NITROSO-N-METHYL-N-AMYL-AMINE NITRO-SOMETHYL-N-PENTYLAMINE... 

C7H6N604 5-(N-methyl-N-nitroso)amino-3-(5-nitro-2-fur 41735-28-8 25.00 1.6632 2 10525 C7H7CIO 5-chloro-o-cresol 5306-98-9 19.83 1.1954 2... 

Amino-1-methyl-4-nitro- 629 5-Amino-1-methyl-4-nitroso- 688... 

Aldrich (1989) developed an apparatus for the non-hazardous preparation of diazomethane from l-methyl-3-nitro-l-nitroso guanidine (2.45, R = R = H), which is convenient for the generation of one mmole or less of diazomethane, and three kits for the generation from Ar-methyl-AT-nitroso-4-toluenesulfonamide (Diazald) for the preparation of up to 50, 100, or 200 mmoles, based in part on a design of Hudlicky (1980). These kits allow generation of diazomethane solutions in a closed system. Such systems are necessary due to the extreme toxicity of diazomethane, causing pulmonary edema when the vapor is inhaled. 

Analysis of Reagent Purity diazomethane is titrated by adding a known quantity of benzoic acid to an aliquot of the solution such that the solution is colorless and excess benzoic acid remains. Water is then added, and the amount of benzoic acid remaining is back-titrated with NaOH solution. The difference between the amount of acid added and the amount remaining reveals the amount of active diazomethane present in the aliquot. Preparative Methods diazomethane is usually prepared by the decomposition of various derivatives of A-methyl-iV-nitroso-amines. Numerous methods of preparation have been described,. but the most common and most frequently employed are those which utilize N-Methyl-N-nitroso-p-toluenesulfonamide (Diazald 1), l-Methyl-3-nitro-l-nitrosoguanidine (MNNG, 2)f oriV-methyl-Mnitrosourea (3) ... 

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