Methyl acylation

Benzimidazole, 2-amino-5-bromo-l-methyl-diazo coupling, 5, 429 Benzimidazole, 2-amino-6-bromo-1 -methyl-diazo coupling, 5, 429 Benzimidazole, 2-amino-1-ethyl-alkylation, 5, 438 Benzimidazole, 2-amino-1-methyl-acylation, 5, 438 bromination, 5, 429 tautomerism, 5, 368 Benzimidazole, 4-amino-2-methyl-diazo coupling, 5, 429 Benzimidazole, 2-aroyl-mass spectra, 5, 360 Benzimidazole, 1-aryl-metallation, 5, 448 reactions... 

Pteridine, 2,4-diamino-6-methyl-acylation, 3, 295 hydrolysis, 3, 294 synthesis, 3, 311... 

Pyrido[2,3-6]pyrazine, 8-hydroxy-tautomerism, 3, 250 Pyrido[2,3-h]pyrazine, methyl-acylation, 3, 253 Pyrido[2,3-6]pyrazine, 2-oxo-oxidation, 3, 250-251... 

Pyrido[2,3-(i]pyrimidine, /3-ketoalkyl-deacylation, 3, 212 Pyrido[2,3-(i]pyrimidine, methyl-deuterium exchange, 3, 212 Pyrido[2,3-(i]pyrimidine, 2-methyl-acylation, 3, 210... 

Enzymes catalysing the transfer of a chemical group, (transfer methyl, acyl, etc.) (EC 2.1 - 2.9) EC2.1 Transf. one-carbon groups (nicotinamide N- Adenylate/creatine kinase/firefly AMP, ADP, ATP ATP Luciferin / Mg21- 19... 

Racemase deficiency. The biological role of 2-methyl-acyl-CoA racemase has only recently been clarified. This peroxisomal enzyme is essential for certain steps of the oxidation of phytol and bile acid derivatives, which are stereospecific. Biochemically there is accumulation of pristanic acid and C27 bile acid intermediates. Clinical symptoms may include adult-onset peripheral neuropathy, pigmentary degeneration of the retina and liver disease [ 13]. 

D-bifunctional protein deficiency [5], 2-methyl acyl-CoA racemase (AMACR) deficiency [3] and sterol carrier protein (SCP-x) deficiency [6], the disorders of etherphospholipid biosynthesis (dihydroxyacetone phosphate acyltransferase and alkyl- dihydroxyacetone phosphate synthase deficiency) [2], the disorders of phytanic acid alpha-oxidation (Refsum disease) [15], and the disorders of glyoxylate detoxification with hyperoxaluria type 1 as caused by alanine glyoxylate aminotransferase deficiency as a sole representative. 

Table 3.4.1 Levels of very-long-chain fatty acids (VLCFA), pristanic acid and phytanic acid in the different peroxisomal disorders. AMACR 2-methyl acyl-CoA racemase, N normal, RCDP rhizomelic chondrodysplasia punctata, SCP-x sterol carrier protein, ZSDs Zellweger spectrum disorders,...

Carbohydrate postglycosylation modifications, including methylations, acylations, and attachment of complex chromophores, are also used for glycodiversification of NPs in chemoenzymatic approaches. 

F Schauwecker, F Pfennig, N Grammel, U Keller. Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides. Chem Biol 7 287-297, 2000. 

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