Methoxyflurane 2,2 dichloro

Methoxyflurane Methoxyflurane, 2,2-dichloro-l,l-difluoroethylmethyl ether (1.1.10), is synthesized from l,l-difIuoro-2,2,2-trichIoroethane, which undergoes dehydrochlorina-tion by potassium hydroxide to give l,l-dichloro-2,2-difluoroethylene (1.1.9) to which methanol is added in the presence of potassium hydroxide [8]. 

Chlorofluorocarbon (CFC) replacements have recently been used for their lower stability and because they have carbon-hydrogen bonds, which means that their atmospheric lifetime is expected to be much shorter than those of CFCs. The adsorption properties of l,l,2-trichloro-l,2,2-trifluoroethane (CFC 113) and its replacement compounds, l,l-dichloro-2,2,2-trifluoroethane (HCFC123), 1,1-dichloro-l-fluoroethane (HCFC141b), and l,l-dichloro-l,2,2,3,3-pentafluoropropane (HCFC225ca) on four kinds of activated carbons were investigated. The adsorption isotherms of inhalational anesthetics (halothane, chloroform, enflurane, isoflurane, and methoxyflurane) on the activated carbon were measured to evaluate the action mechanism of inhalational anesthesia. The anesthesia of CFC replacements can be estimated by the Freundlich constant N of the adsorption isotherms (Tanada et al., 1997). 

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