Methoxatin,co-enzyme

Methoxatin 267 is a bacterial co-enzyme that allows the oxidation of methane to more useful one-carbon compounds. The 1,2-dione in the middle ring is the powerhouse of the molecule and can be made from the simpler aromatic compound 268 by oxidation. Oxidative cyclisation of the Z-alkene 269 might give 268. 

The co-enzyme methoxatin (13), a constituent of bacterial methanol dehydrogenases, has excited considerable interest since... 

Pyrroloquinolinequinone (213) (2,7,9-tricarboxy-l/7-pyrrolo[2,3-/]quinoline-4,5-dione, PQQ) (trivial name methoxatin) has been identified as a co-factor in many enzymes, including those that oxidize MeOH to HCHO in methylotrophic and autotrophic bacteria. Quinoproteins appear in mammalian systems as well, and methoxatin itself (213) has even been identified as an inhibitor of HIV-1 reverse transcriptase (for PQQ reviews, see <91MI 722-02, 95MI 722-02)). Interest in under-... 

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