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Methotrexate analogues as anticancer drugs

Another class of much used drugs, interfering with the synthesis of DNA, acts by inhibiting dihydrofolate hydrogenase. This is the enzyme that reduces dihydrofolic acid to 5,6,7,8-tetrahydrofolic acid, a substance only one step short of the coenzymes for synthesis of the purine bases and thymine. Analogues of folic acid, based on 2,6-diaminopteridine, such as methotrexate (4.6), are useful anticancer drugs (see Section 9.3c) but... [Pg.108]

See other pages where Methotrexate analogues as anticancer drugs is mentioned: [Pg.389] [Pg.397] [Pg.349] [Pg.463] [Pg.585] [Pg.395] [Pg.276] [Pg.389] [Pg.397] [Pg.349] [Pg.463] [Pg.585] [Pg.395] [Pg.276] [Pg.8] [Pg.219]

See also in sourсe #XX -- [ Pg.25 , Pg.85 ]

See also in sourсe #XX -- [ Pg.25 , Pg.26 , Pg.85 ]

See also in sourсe #XX -- [ Pg.25 , Pg.26 , Pg.85 ]

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Anticancer drugs

Anticancer drugs methotrexate

Methotrexate