Methanesulfonyl Chloride related reagents

Preparative Methods The enantiopure sulfonamide la is prepared via sulfonylation of (7 ,7 )-l,2-diaminocyclohexane 2 in the presence of an excess of triethylamine (eq 1). Use of excess amine base is essential for obtaining a high yield of the bis-sulfonamide. Synthesis of related bis-sulfonamides is easily accomplished by substituting the desired sulfonyl chloride in the former procedure. Recrystallization of the bis-sulfonamide la from hexane/ethyl acetate and drying over P2O5 allows for isolation of the analytically pure reagent. Methanesulfonyl chloride and (7 ,/ )-l,2-diaminocyclohexane 2 are commercially available from a number of sources. However it should be noted that racemic 1,2-diaminocyclohexane 2 can be resolved via formation of the tartrate salt. Typically, the diamine can be obtained in >99 1 enantiomeric ratio (er) after two crystallizations from water. Determination of the enantiopurity of the diamine is accomplished via formation of the bis-3-toluyl amide and anal-... 

Related Reagents. ferf-Butylsulflnyl Chloride Di-teri-butyl Disulfide Benzenesulfonyl Chloride Methanesulfonyl Chloride 2-Nitrobenzenesulfonyl Chloride 4-Nitrobenzenesulfonyl Chloride 2,4-Dinitrobenzenesulfonyl Chloride. ... 

Related Reagents. Polymer-supported Methanesulfonyl Chloride Toluenesulfonyl Chloride Methanesulfonyl Chloride. 

Related Reagents. Methanesulfonyl Chloride Mesitylene-sulfonyl Chloride IV-Phenyltrilluoromethanesulfonimide p-Toluenesulfonyl Chloride Trifluoromethanesulfonyl Chloride. 

Related Reagents. Benzenesulfonyl Chloride 4-Bromo-benzenesulfonyl Chloride Mesitylenesulfonyl Chloride Methanesulfonyl Chloride p-Toluenesulfonyl Chloride Tri-fluoromethanesulfonic Anhydride. 

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See also in sourсe #XX -- [ ]

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