Methanamine complexes

The polymorphism encountered with l-(5- [(2R,3S)-2-( (lR)-l-[3,5-Bis(trifluoromethyl)phenyl] ethyl oxy)-3-(4-fluorophenyl)morpholin-4-yl]methyl -2H-l,2,3-triazol-4-yl)-A,A-dimethyl-methanamine hydrochloride (Compound A, hereafter), a high-affinity, orally active h-NKl receptor antagonist (Harrison et al. 2001), illustates the complexity of solid phase behavior. 

PENTAKIS(METHANAMINE)-(TRIFLUOROMETHANESULFONATO-O) COMPLEXES OF CHROMIUM(III), COBALT(III), AND RHODIUM(III)... 

The ruthenium complex [Ru(N3P)(OAc)][BPh4], in which N3P is the N,P mixed tetradentate ligand A,A-bis[(pyridin-2-yl)methyl]-[2-(diphenylphosphino)phenyl] methanamine, was found to be catalytically active for the endo cycloisomerization of aliphatic aUcynols to five-, six-, and seven-membered endo-cyc c enol ethers in good to excellent yield (Scheme 13) [102, 103]. 

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