Methadone description

Fora complete description of detoxification and maintenance regulations and dosage protocols, consult a local approved methadone program. 

The previous edition of this book contained a detailed description of abuse of the antiemetic tablet preparation cyclizine by illicit drug users, nearly always crushed and injected along with methadone tablets or ampoules. Cyclizine is a constituent of Diconal along with the opioid dipipanone, and it seems that cyclizine has an opioid-enhancing effect which partly accounts for the particularly euphoriant property of Diconal. This could therefore be reproduced by combining cyclizine with the synthetic opioid methadone, and the intention to do this led to a wave of patients in the UK attempting to have their methadone prescribed in the ampoule or tablet form. 

Myton T Fletcher K (2003). Descriptive study of the effects of altering formulation of prescribed methadone from injectable to oral. Psychiatric Bulletin, 27, 3-6... 

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