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Metallothionein a Stress Protein

Metallothionein (MT) is a low-molecular-weight metal-binding protein well known to toxicologists who study metals. The protein is believed to play an important role in the homeostasis of the essential micronutrients zinc and copper, but also influences the metabolism and toxicity of other metals, such as cadmium, mercury, and copper. [Pg.247]

Is MT a stress protein In this section, the following common properties of MTs and stress proteins will be compared evolutionary conservation, common inducers, protective roles and cross-tolerance, gene regulation, increased expression of these proteins in neoplasms and other disease states, and as adjuncts in chemotherapy. Since the two classes of proteins represent many proteins, we will speak of them in a generic sense for the purposes of this discussion. The discussion will include many generalizations and [Pg.247]


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