Metallo-macrocycles self-assembly

Kay Severin s group has previously investigated the preparation of dynamic combinatorial libraries of metallo-macrocycles for use as sensors for Li+ at physiologically relevant conditions [59]. For example, they have found that ligand 62 and metal complexes 63 undergo a self-assembly process to yield the trimeric complexes depicted in Scheme 4.15 [60]. Mixtures of 64 and... 

Self-assembly of chiral metallo-macrocycles using trifunctional assembling mono-anionic and dianionic ligands. 

Another interesting development has been the self-assembly of metallo-dithiocarbamate macrocychc receptors for electrochemical anion sensing. The naphthyl-based Cu(II) macrocycle 48 displays a cathodic shift of 85 mV in the Cu(II)/(III) redox couple in the presence of dihydrogenphosphate or perrhenate, but gives no response to hahdes in acetonitrile solution [35]. It is proposed that this selectivity is controlled by cavity size. A related receptor incorporating thiourea and hydrogen-bond donor groups, 49, revealed... 

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