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Metalla-cages

The spherical metalla-cages [M2Ni4(atu)8X]3+ (M=Ni, 8a,b Pd, 9a,b X=C1, Br) have also been prepared by an anion templated process. These species can be obtained by reacting Ni(atu)2 with NiX2 and [PdX2(PhCN)2] respectively. Once again the formation of these metalla-assemblies is highly dependent on the pres-... [Pg.97]

Scheme 7 The syntheses of the metalla-cages and metaUa-macrocydes shown in this scheme is highly dependant on the nature of the anions present in solution. Hydrogen bonding interactions with the templating halides play an essential part in the templated process... Scheme 7 The syntheses of the metalla-cages and metaUa-macrocydes shown in this scheme is highly dependant on the nature of the anions present in solution. Hydrogen bonding interactions with the templating halides play an essential part in the templated process...
Fig. 10 Guest-adaptable metalla-cage [ (/)Pr C6H4Mc)Ru 6( i-L4)6(tpt)2, empty (left) and encapsulating two coronene molecules (right) (coronene being represented by space-filling model) [38]... Fig. 10 Guest-adaptable metalla-cage [ (/)Pr C6H4Mc)Ru 6( i-L4)6(tpt)2, empty (left) and encapsulating two coronene molecules (right) (coronene being represented by space-filling model) [38]...
Fig. 12 Organometallic metalla-cages IpyrcncC (/)Pr C6H4Mc)Ru 6().i-tpt)2(. i-dlibq)1 6+ (a) [45] and fhexamethoxytriphenyleneC (pPriC6H4Me)Ru 6(p-tpt)2(p.-dhbq)3]6+ (b) (guest molecules being represented by space-filling models) [46]... Fig. 12 Organometallic metalla-cages IpyrcncC (/)Pr C6H4Mc)Ru 6().i-tpt)2(. i-dlibq)1 6+ (a) [45] and fhexamethoxytriphenyleneC (pPriC6H4Me)Ru 6(p-tpt)2(p.-dhbq)3]6+ (b) (guest molecules being represented by space-filling models) [46]...
Fig. 16 Trojan horse concept illustrated by the platinum bisacetylacetonate complex being encapsulated in the metalla-cage, [Pt(acac)2C (pPr1C6H4Me)Ru 6(p-dhbq)3(tpt)2]6+ (Pt(acac)2 being represented by space-filling model) [59]... Fig. 16 Trojan horse concept illustrated by the platinum bisacetylacetonate complex being encapsulated in the metalla-cage, [Pt(acac)2C (pPr1C6H4Me)Ru 6(p-dhbq)3(tpt)2]6+ (Pt(acac)2 being represented by space-filling model) [59]...
The encapsulation of a fluorescent pyrenyl derivative, l-(4,6-dichloro-l,3,5-triazin-2-yl)pyrene (pyrene-R), has provided direct evidence for the release of a hydrophobic molecule from the metalla-cage [ (p v C6 A Me)Ru 6(p-dhbq)3 (tpt)2]6+> following uptake into cancer cells [61]. The fluorescence of pyrene-R has allowed monitoring of cellular uptake and accumulation, as well as an estimation of the efficiency of the [pyrene-Rc (/tPr C6H4Me)Ru 6((i-dhbq)3(tpt)2]6+ system to transport and release its cargo (Fig. 17). [Pg.49]

Fig. 18 Organometallic metalla-cages [pyrene-Rc (pPriC6H4Me)Ru 6((i-donq)3(tpt)2]6+ (a), [pyrene-Rc (pPr1C6H4Me)Ru 6(p-doaq)3(tpt)2]6+ (b) and [pyrene-Rc (pPr1C6H4Me)Ru 6 (p-dotq)3(tpt)2]6 (c), showing the width of the portals (pyrene-R being represented by spacefilling models) [62]... Fig. 18 Organometallic metalla-cages [pyrene-Rc (pPriC6H4Me)Ru 6((i-donq)3(tpt)2]6+ (a), [pyrene-Rc (pPr1C6H4Me)Ru 6(p-doaq)3(tpt)2]6+ (b) and [pyrene-Rc (pPr1C6H4Me)Ru 6 (p-dotq)3(tpt)2]6 (c), showing the width of the portals (pyrene-R being represented by spacefilling models) [62]...
Fig. 19 Molecular structure of [P2C (pPr1C6H4Me)Ru 6(p-donq)3(tpt)2]6+ showing the pyrenyl-modified dendrimer (P2) (space-filling model) being encapsulated in the cavity of the metalla-cage [63]... Fig. 19 Molecular structure of [P2C (pPr1C6H4Me)Ru 6(p-donq)3(tpt)2]6+ showing the pyrenyl-modified dendrimer (P2) (space-filling model) being encapsulated in the cavity of the metalla-cage [63]...
Mattsson J, Zava O, Renfrew AK, Sei Y, Yamaguchi K, Dyson PJ, Therrien B (2010) Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton Trans 39 8248-8255... [Pg.56]

Zava O, Mattsson J, Therrien B, Dyson PJ (2010) Evidence for drug release from a metalla-cage delivery vector following cellular internalisation. Chem Eur J 16 1428-1431... [Pg.56]

Barry NPE, Zava O, Dyson PJ, Therrien B (2011) Excellent correlation between drug release and portal size in metalla-cage drug delivery systems. Chem Eur J 17 9669-9677... [Pg.56]

The first examples of metalla-cages synthesized by anion-directed processes are a series of polyoxometallates reported by Muller.In these species, anions control... [Pg.53]

Figure 3.13 Example of a Ru(ll) p-cymene metalla-cage employed for drug delivery. Adapted from Ref. [75]. Figure 3.13 Example of a Ru(ll) p-cymene metalla-cage employed for drug delivery. Adapted from Ref. [75].
See other pages where Metalla-cages is mentioned: [Pg.39]    [Pg.43]    [Pg.43]    [Pg.44]    [Pg.49]    [Pg.50]    [Pg.50]    [Pg.50]    [Pg.50]    [Pg.52]    [Pg.53]    [Pg.444]   
See also in sourсe #XX -- [ Pg.91 , Pg.92 , Pg.130 ]



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