Metal-free iodine-promoted oxidative cyclization

Metal-free iodine-promoted oxidative cyclization domino process was successfully utilized by Jiang et al. [15] to synthesize poly substituted oxazoles. Similarly, very efficient iodine-promoted oxidative cyclization domino process was reported by Wu et al. [16] for the synthesis of 2-acylbenzothiazoles 38 via a sp C-H functionalization (Scheme 9.8). 

The hypervalent iodine reagent PhI(OTf)2 (generated in situ) promotes the metal-free oxidative production of C-O bonds, through an intramolecular oxidative cyclization of substituted N-styrylbenzamides 131 to give oxazoles 132 (13SL2119). 

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