Metal-Catalyzed Four-Component PBM Reaction

Although the aforementioned method proceeds with high regio- and stereocontrol, the synthetic scope is limited by the 

The method was efficient for primary, secondary, and tertiary alcohols and tolerated benzyloxy and carbethoxy/ methoxy groups (Table 4.2). The four-component coupling reactions proceeded very cleanly, with formation of a single product with a very high selectivity, affording final a-amino acid derivatives 37a-k as single regio- and stereoisomers from a variety of available allyl alcohols 31. 

FIGURE 4.1 Mode of dual activation in the Petasis reaction. 

SCHEME 4.17 One-pot synthesis of a-amino acids via catalytic generation of allyl boronates. 

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