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Metal-catalyzed couplings pyrimidines

A chlorine substituent in the highly electrophilic 2-position is very reactive towards nucleophiles. With lithium or sodium organics the reported reactions seem to indicate adduct formation and hydrogenolysis in addition to substitution <81RCR816>. Metal-catalyzed coupling reactions, as discussed for pyrimidines, are expected to provide for versatile carbosubstitutions. [Pg.151]


See other pages where Metal-catalyzed couplings pyrimidines is mentioned: [Pg.534]    [Pg.362]    [Pg.230]    [Pg.233]    [Pg.362]    [Pg.136]    [Pg.150]    [Pg.313]    [Pg.409]    [Pg.35]    [Pg.1348]    [Pg.119]    [Pg.495]    [Pg.148]    [Pg.348]    [Pg.650]    [Pg.317]   
See also in sourсe #XX -- [ Pg.127 , Pg.128 , Pg.129 ]




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Metal catalyzed coupling

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