Metabolomics hyphenation

MS (MS/MS) experiments were able to characterize the structures of some of ions in this sample. The advantage of this type of direct-infusion approach is that they are extremely fast, but depth is sacrificed for speed. Therefore, the majority of MS metabolomics studies rely on hyphenated approaches, including LC-MS. 

NMR metabolomics increasingly makes use of natural product structure elucidation techniques such as 2D NMR, particularly for plant-based studies. In both natural products research and metabolomics, strategies such as quantitative NMR and low-volume NMR are employed, while the use of hyphenated NMR techniques is also expanding. These techniques have been applied in numerous studies examples are given in Table 1 (see also Volume 9). 

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