Metabolite production chrysogenum

Chrysogine.—Production of chrysogine (159), a metabolite of Peniciltium chrysogenum, has been found to be stimulated by added anthranilic acid, a likely precursor, but lactic acid, a possible source of the remaining three carbons, caused a decrease in the yield. 

Figure 6.16 Flow chart for the development of a large-scale industrial fermentation. The organism, in this case Penicillium chrysogenum, is grown up in stages from the stored organism, in this case lyophilized spores, until there is enough growth to inoculate the production fermenter. Only at this stage is the production of the metabolite, here penicillin, stimulated...

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