Metabolism antipsychotic drugs affecting

Fluoxetine and paroxetine inhibit cytochrome CYP P-450 2D6 and thus may affect metabolism of some opioids, e.g. codeine, 0) codone and tramadol, that are partly metabolised by CYP2D6, many antipsychotic drugs and tricyclic antidepressants. 

Pharmacokinetic interactions between acute and chronic alcohol ingestion, and single or multiple doses of antipsychotic drug are complex acute alcohol intake can decrease metabolic clearance, whereas chronic intake can increase clearance. Alcohol may also affect the peripheral circulation and membrane permeability, which might affect absorption from an injection site. ... 

The basic—but oversimplified—notion regarding antipsychotic medications is that they primarily affect the reticular activating system, the limbic system, and the hypothalamus. The effects on the reticular activating system generally moderate spontaneous activity and decrease the patient s reactivity to stimuli. The action within the limbic system serves to moderate or blunt emotional arousal. These actions arc thought to produce the drug s dramatic effects on schizophrenic or agitated behavioral patterns. The effects on the hypothalamus help modulate metabolism, alertness, and muscle tone. Because of these effects, antipsychotics arc the major approach to... 

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