Mesoridazine Phenytoin

Mesoridazine Phenytoin Reduced effect of phenytoin interaction poorly documented Unknown... 

In a large study in patients taking phenytoin with various phenothiazines (chlorpromazine, tMoridazine or mesoridazine), phenytoin levels were decreased by 44% when the phenothiazines were started, and by 33% when the phenothiazine dose was increased. A number of patients experienced an increased frequency of seizures. In patients who had these phenothiazines discontinued or the dosage decreased, the phenytoin levels increased by 55% and 71%, respectively, and toxic levels occurred in some patients. ... 

The concentration of the active metabolite mesoridazine falls more markedly. Phenytoin and phenobarbital reduce furosemide absorption. 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, amitriptyline, amobarbital, amoxapine, antipsrrine, atenolol, atropine, azata-dine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorqyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimetidine, cisapride, clomipramine, clonazepam, clonidine, clozapine, cocaine, codeine, colchicine, qyclizine, (yclo-benzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, diltiazem, diphenhydramine, diphenidol, dipheno late, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvoxamine, fii-rosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydro g chloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, le-vorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephenytoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methoxamine, methyl-dopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, oxymetazo-line, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenytoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propafenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethyl-perazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimeprazine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Simultaneous amitriptyline, amobarbital, butalbital, carbamazepine, chlordiazepoxide, chlorpromazine, clonazepam, demoxepam, desipramine, diazepam, ethinamate, fluraze-pam, glutethimide, heptobarbital, hexobarbital, lidocaine, medazepam, meperidine, mephobarbital, mesoridazine, methaqualone, pentathal, nortriptyline, oxazepam, pentobarbital, perphenazine, phenytoin, promazine, propranolol, protriptyline, quinidine, secobarbital... 

Also analyzed acetaminophen, alprazolam, amitriptyline, amoxapine, carbamazepine, chlordiazepoxide, chlorpromazine, chlorprothixene, clonazepam, demoxepam, desipra-mine, diphenhydramine, disopyramide, doxepin, ethotoin, flurazepam, glutethimide, hal-operidol, haloperidol, imipramine, lidocaine, lorazepam, loxapine, maprotiline, mesantoin, mesoridazine, methaqualone, methotrimeprazine, nordiazepam, nortriplyline, oxazepam, pentazocine, perphenazine, phenacetin, phenobarbital, phenytoin, promazine, promethazine, propranolol, protriptyline, salicylic acid, thiothixene, trifluoperazine, trifluproma-zine, trimipramine... 

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