MERQ equations

The total mass transfer rates are added to an expanded set of the MESH equations called the MERQ equations. The new MERQ acronym stands for... 

The influence of these structural changes on the UpophiUcity/hydrophobicity properties of the resulting analogs was investigated. The distribution coefficients (log D) were determined at cytosolic pH (7.4) and vacuolar pH (5.2) by HPLC [60]. In addition, the ionization proportion of neutral, monoprotonated, and diprotonated forms was determined by the Henderson-Hasselbach equation from experimental p/Q values [60]. It has been shown that all compounds are highly hydrophilic at vacuolar pH (5.2) and are mostly in their diprotonated form. At this pH, the lipophilicity of these analogs can be ranked as follows MeRQ > MeFQ > RQ > FQ > CQ. At vacuolar pH, the differences between the coefficients of distribution are small. In addition, replacing the iron atom of FQ by ruthenium in RQ has no influence on the lipophilicity of the molecules. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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