Meropenem dosage

Empirical regimens containing Cefepime, ceftazidime, imipenem, meropenem Vancomycin dosages may be adjusted based on... 

Recommended Meropenem IV Dosage Schedule for Adults with Impaired... 

Children The safety and efficacy of meropenem have not been established for children younger than 3 months of age (see Administration and Dosage). 

Although there is only an isolated report of an interaction between valproate and imipenem, there are now several reports of the interaction between valproate and meropenem or panipenem. Seizures or increased seizure frequeney have been reported. It would therefore seem prudent to monitor the valproate levels in any patient also given carbapenems, being alert for the need to increase the valproate dosage, or to use another antibacterial, or an alternative to valproate. Carbamazepine and phenytoin did not interact in the above reports. The manufacturers of ertapenem have no reports of an interaction on their files, but prudently warn about a possible interaction with valproate because of the interactions seen with other carbapenems. 

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