Mepron - Atovaquone

Atoivastatin (Lipitor) Antihyperlipid-emic Tab 10, 20, 40 mg Atovaquone (Mepron) Antiprotozoal Susp 750 mg/5 ml... 

Atovaquone (Mepron) [Antiprotozoal] Uses Rx prevention PCP Action 4- nucleic acid ATP synth Dose Rx 750 mg PO bid for 21 d Prevention 1500 mg PO once/d (w/ meals) Caution [C, ] Disp Susp SE FevCT, HA, anxiety, insomnia, rash, N/V Interactions X Effects W/ metoclopramide, rifabutin, rifampin, tetracycline EMS None OD Sxs unknown but may cause a rash symptomatic and supportive... 

MEPRON suspension is a formulation of microfine particles of atovaquone. The atovaquone particles, reduced in size to facilitate absorption, are significantly smaller than those in the previously marketed tablet formulation. MEPRON suspension is for oral administration and is... 

Clinical Use. Atovaquone (Mepron) is used primarily to treat the protozoon that causes toxoplasmosis and the fungus that causes pneumocystis pneumonia in immunocompromised patients.6 This drug is not typically the primary treatment for pneumocystis, but is often reserved for patients who cannot tolerate more traditional treatments using sulfamethoxazole and trimethoprim (see Chapter 34) or pentamidine (see later). Atovaquone can also be used to prevent and treat resistant cases of malaria, and the antimalarial effects of this drug seem especially useful when combined with proguanil.48... 

Atovaguone, USP.. 3- 4-(4-Chlorophenyl)-cyclohexyl -2-hydroxy-1.4-naphthoquinone (Mepron) is a highly lipophilic, water-insoluble analogue of ubiquinone 6. an es.sen-tial componcni of the mitochondrial electron transport chain in micmorganism.s. The. structural similarity between atovaquone and ubiquinone suggests that the former may act as an antimctabolilc for the latter and thereby interfere with the function of electron transport en/ymes. 

Atovaquone (mepron) has potent activity against Plasmodium species and the opportunistic pathogens Pneumocystis jirovici arul Toxoplasma gondii it is FDA approved for treatment of P. jirovici pneumonia in patients intolerant of trimethoprim-sulfamethoxazole. In patients with uncomplicated P. falciparum malaria, combination therapy with proguanil and atovaquone evoked high cure rates with few relapses and minimal toxicity. A fixed combination of atovaquone with proguanil (maiarone) is available in the U.S.for malaria prophylaxis and treatment. 

Mepron Suspension (Atovaquone). Gl oSmithKUne. US Prescribing information, November 2006. 

Sadler BM, Caldwell P, Scott JD, Rogers M, Blum MR. Drug interaction between rifempin and atovaquone (Mepron ) in HIV+ asymptomatic volunteers. Intersci C[Pg.214]

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