Membrane pore formation, microbial

Lysis of the target cell membrane. This involves a collection of complement proteins associating upon the surface of a microbial membraneto form a membrane attack complex (MAC), which leads to the formation of membrane pores and, ultimately, microbial cell lysis. 

A novel bioassay for nystatin based on the use of a microbial sensor was recently reported. Nystatin is believed to bind to the steron present in the membranes of sensitive cells, leading to the formation of pores. The subsequent death of the microorganism is preceded by leakage of cellular materials. Microbial death can be detected by means of an oxygen electrode. 

---