Membrane development rationale

The rationale for the development of such fibers is demonstrated by their appHcation in the medical field, notably hemoperfusion, where cartridges loaded with activated charcoal-filled hoUow fiber contact blood. Low molecular weight body wastes diffuse through the fiber walls and are absorbed in the fiber core. In such processes, the blood does not contact the active sorbent direcdy, but faces the nontoxic, blood compatible membrane (see Controlled RELEASE TECHNOLOGY, pharmaceutical). Other uses include waste industrial appHcations as general as chromates and phosphates and as specific as radioactive/nuclear materials. 

The most likely identity of these components are the membrane lipids. We suggest, therefore, that the primary reaction of ozone with the envelope membranes involves the disorganization of the membranes via constituents other than the lipids. A similar possibility has been developed by Mudd al. (17) who found that ozone does not react readily with lecithin when in a bilayer configuration. In addition, Swanson et al. ( ) reported that the electron microscopic image of most cellular membranes is not affected by prior treatment with ozone. The rationale in their discussions is that the architecture of the membrane restricts the ability of ozone to react with the olefinic groups. 

PURPOSE AND RATIONALE Drags developed for local application to mucosal membranes of the eye, mouth, membranes of the penis, vagina and rectum have to be tested for local tolerance as well. However, for testing of locally irritating effects findings from toxicology studies with repeated administration to mucosal membranes are more suitable than acute studies developed mainly for testing of industrial chemicals. 

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