Melting Time of Suppositories

Many suppository bases are made up of various acylglycerols. Hardening of suppositories is considered to result from various phase transitions, crystallization, and transesterification reactions in these lipids. The DSC thermograms of a semisynthetic, hard base triglyceride shown in Fig. 177 indicate that a polymorphc phase transition occurred during storage.709 

Changes in melting properties during storage were also reported for effervescent suppositories even when stored at 25°C this indicated that these products should be stored below 15°C (Fig. 178).710 

Changes in Drug Release Rate from Polymeric Matrix Dosage Forms, Including Microspheres 

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Figure 175. Changes in the melting time of suppositories following storage at 20°C. (Reproduced from Ref. 707 with permission.)...

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