Melatonin analogs

Pharmacomodulated melatonin analogs were prepared by Berteina-Raboin et al. using SPOS [33]. C-2 carbon functionalized 5-carboxamido-... 

Figure 10.4 Chemical structures of the clinically relevant melatonin analogs, compared with melatonin (5-methoxy-N-acetyltryptamine). Agomelatine N- 2-[7-methoxy-l-naphthalenyl]ethyl)acetamide. Ramelteon ...

Scheme 65 Solid-phase synthesis of a melatonin analog...

Indolyl-l-nitroalkanes 22 are highly versatile intermediates for the preparation of several biologically active compounds such as melatonin analogs 23, l,2,3,4-letrahydro-()-carbolines 24 and triptans 25 (Scheme 8) [45]. 

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