Melanoidins nondialyzable

Studies with 15N-nondialyzable melanoidin showed that 76% of the dietary melanoidin was excreted in rats feces (59). 

Homma, S. Fujimaki, M. Growth response of rats fed a diet containing nondialyzable melanoidin. Prog. Food Nutr. Sci. 1981, 5, 209-16. 

The optimal conditions and kinetics of the formation of nondialyzable melanoidins responsible for the brown color of caramel is now under study in various model systems. For the D-glucose-glydne model system at 110°, the rate constants are 4.55 X 10 Vs and 9.40 X 10" /s for the molar sugar amino add ratios 2.5 1 and 1 2.5, respectively. Rates for other... 

A great deal of work has been devoted to recognition of the structure of melanoidins. A wide variety of methods has been employed for this purpose. First, melanoidin shows a hyperfine structure in the e.s.r. spectrum and that means that stable free-radicals are present in caramel. Amino acids and ammonia were also detected in nondialyzable melanoidin after acid hydrol-ysis, indicating that amides are present in melanoidin. 

Table 5. Desmutagenicity of nondialyzable melanoidins (MEL) prepared from glucose and various amino acids, peptides or egg albumin hydrolysate at 110°C, pH 7.0 for 1 h, 2 h or 95 °C, pH 7.0 for 7 h against Trp-P-1...

Nondialyzable melanoidins (2 mg/plate) Desmutagenicity Revertants/plate ... 

Fraction numbers are I, Lyophilized fraction II, Nondialyzable fraction and III, Melanoidins isolated from nondialyzable fraction by Sephadex G-25 and G-lOO column chromatography. 

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