Melanin production, disorder

Vitamin C (L-ascorbic acid Figure 37.41) can limit melanin production, as it has a tyrosinase-inhibiting and antioxidant activity. Skin cells naturally use ascorbic acid in energy metabolism and when synthesizing collagen. A deficiency in vitamin C is a well-known cause of many disorders, including hyperkeratotic folliculitis and delayed wound healing. 

Lack of melanin production (hypomelanosis) gives rise to several hereditary disorders collectively known as albinism. Some forms result from deficiency of tyrosinase. The inheritance pattern of albinism varies with type. Affected individuals have increased susceptibility to various... 

Hydroquinone is applied topically to treat disorders characterized by excessive melanin in the epidermis, such as melasma. In the United States, nonprescription skin-lightening products contain hydroquinone at concentrations of 2% or less higher concentrations are available by prescription. 

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