Mefloquine Valproate

Mefloquine Valproate Reduced effect of valproate interaction poorly documented Unknown... 

Mefloquine has been reported to oppose the effect of valproate (58). 

An isolated report deseribes a 20-year-old woman, with a 7-year history of epilepsy (bilateral myoelonus and generalised tonic-clonic seizures) controlled with sodium valproate 1.3 g daily, who developed tonic-clonic seizures 8 hours after taking the second of 3 prophylactic doses of mefloquine 250 mg. It is not clear whether this resulted from a drug-drug or a drug-disease interaction. The manufacturers of mefloquine advise its avoidance in those with a history of convulsions as it may increase the risk of convulsions. In these patients mefloquine should he used only for curative treatment if compelling reasons exist. ... 

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