Meerwein rearrangement cascad

Meerwein Rearrangement Cascades ( Tandem Wagner-Meerwein Rearrangements ) in Biosynthesis... 

Wagner-Meerwein Rearrangements in the Context of Tandem and Cascade Rearrangements... 

S Cascade reactions implementing the Ritter reaction Recent examples of the Ritter reaction have combined this useful synthetic tool with other reactions and rearrangements to produce complex reaction sequences. For example, Bishop has reported the combination of the Ritter reaction with the Wagner-Meerwein rearrangement, which can result in complex and sometimes unpredictable reaction sequences.17 The use of the Ritter reaction to trap cationic intermediates in the CAN-mediated dimerization of alkoxystyrenes has recently allowed the synthesis of a-aminotetralin derivatives by Nair.18... 

In the year 2010, the group of Danishefsky reported the first asymmetric total synthesis of (-)-phalarine by using a Mannich reaction/Wagner-Meerwein rearrange-ment/cyclization cascade sequence (Scheme 13.9) [10], In this reaction cascade, one carbon-nitrogen bond, one carbon-carbon bond, one carbon-oxygen bond, and two new rings were formed. 

Scheme 13.9 Asymetric total synthesis of (-)-phalarine (63) through a Wagner-Meerwein rearrangement/nucleophilic cascade sequence.

A series of carbocyclization cascades of allyl ketenimines initiated through a thermal aza-Claisen rearrangement of A-phosphoryl-A-allyl ynamides has been reported where interceptions of the cationic intermediate via Meerwein-Wagner rearrangements and polyene-type cyclizations are observed (Scheme 17) ... 

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