Medicines establishing differences among

It is well known that water dispersions of amphiphile molecules may undergo different phase transitions when the temperature or composition are varied [e.g. 430,431]. These phase transitions have been studied systematically for some of the systems [e.g. 432,433]. Occurrence of phase transitions in monolayers of amphiphile molecules at the air/water interface [434] and in bilayer lipid membranes [435] has also been reported. The chainmelting phase transition [430,431,434,436] found both for water dispersions and insoluble monolayers of amphiphile molecules is of special interest for biology and medicine. It was shown that foam bilayers (NBF) consist of two mutually adsorbed densely packed monolayers of amphiphile molecules which are in contact with a gas phase. Balmbra et. al. [437J and Sidorova et. al. [438] were among the first to notice the structural correspondence between foam bilayers and lamellar mesomorphic phases. In this respect it is of interest to establsih the thermal transition in amphiphile bilayers. Exerowa et. al. [384] have been the first to report such transitions in foam bilayers from phospholipids and studied them in various aspects [386,387,439-442]. This was made possible by combining the microscopic foam film with the hole-nucleation theory of stability of bilayer of Kashchiev-Exerowa [300,402,403]. Thus, the most suitable dependence for phase transitions in bilayers were established. 

---