Medical treatment adrenaline

Often one of the earliest therapeutic principles a medical student learns is that adrenaline is key in the treatment of anaphylaxis. A very unusual case from Glasgow suggests that this life-saving use of the drug can produce late thrombosis in a drug-eluting coronary stent [61" ]. 

A 43-year-old woman was admitted to hospital with the sudden onset of tongue and periorbital swelling. She had commenced a course of oral flucloxacillin for cellulitis of the left hand. Regular medications included propranolol, lansoprazole, and fexofenadine. She had no known traditional risk factors for coronary artery disease. A diagnosis of anaphylaxis was made probably due to flucloxacillin. She was first treated with intravenous hydrocortisone and chlorphenamine. Despite this treatment, she became profoundly hypotensive. This prompted the intramuscular administration of 0.5mg adrenaline (0.5mL 1 1000 solution). There was inadequate clinical response to the first dose, and so, a second 0.5 mL dose was administered. This resulted in normalization of blood pressure... 

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