Mechanistic Overview

Whereas the demonstration of the ability of allyltin reagents to undergo homolytic cleavage of the carbon-tin bond goes back to the early 1970s ]280], it was only ten years later that Keck and Yates evidenced the synthetic potential of this reaction 

The addition of carbon radicals to allylstannane is not severely affected by their nature, whenever the electrophilic radicals attack the allyltin Jt bond more rapidly than nucleophilic alkyl radicals [286], thus authorizing a wide range of substrates to react. As a consequence, the radical allylic transfer was applied to the synthesis of complex structures such as /3-lactams [287], steroids [288], alkaloids [289] or 

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A variety of double bonds give reactions corresponding to the pattern of the ene reaction. Those that have been studied from a mechanistic and synthetic perspective include alkenes, aldehydes and ketones, imines and iminium ions, triazoline-2,5-diones, nitroso compounds, and singlet oxygen, 10=0. After a mechanistic overview of the reaction, we concentrate on the carbon-carbon bond-forming reactions. The important and well-studied reaction with 10=0 is discussed in Section 12.3.2. 

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The following sections provide a simplified mechanistic overview of phase-transfer catalysis. For more detailed presentations, reference should be made to more modern comprehensive texts [e.g. I -3],... 

Guillaume Lessene and Ken S. Feldman Abstract 479 Introduction 479 Mechanistic Overview 480... 

Howard JB, Rees DC. How many metals does it take to fix N2A mechanistic overview of biological nitrogen fixation. Proc. Natl. Acad. Sci. USA 2006 103 17088-17093. 

General mechanistic overview and ancillary ligand design considerations... 

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Testa, B. Conceptual and mechanistic overview of stereoselective drug metabolism. In Xenobiotic Metabolism and Disposition, Kato, R., Estabrook, R.W., Cayen, M.N., Eds. Taylor and Francis London, 1989 153-160. 

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M. J. Romao, Molybdenum and tungsten enzymes A crystallographic and mechanistic overview, Dalton Trans., 2009, 21, 4053-4068. 

Golding BT and Buckel W (1996) A mechanistic overview of B 12-dependent processes. Abstr Proc Eur Int Symp Vitamin B12 and Bn-Proteins , Vienna, Austria, L34 Golding BT, Anderson RJ, Ashwell S, Edwards CH, Garnett I, Kroll F and Buckel W (1998) A mechanistic overview of B12 dependent processes. In Krautler B, Arigoni D and Golding BT (eds) Vitamin B12 and Bn-proteins, pp 201-216. Wiley-VCH, Weinheim, Chichester, New Y ork... 

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W. Sand Microbial mechanisms of deterioration—a general mechanistic overview,... 

Scheme 7.11 Mechanistic overview of the Schmidt reaction of hydroxyalkyl azides with ketones...

W. Sand, Microbial mechanisms of deterioration—A general mechanistic overview, Int. Biodeterior. Biodegrad. 40 183-190 (1998). 

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