Mechanism and Stereoselectivity in Organocatalytic Cascade Reactions

The efforts to put together the advantages of different organocatalytic protocols have given rise to the invention of cascade as well as one-pot reactions [44]. Any 

The initial experimental report due to Enders and coworkers demonstrated that diarylprolinol trimethylsilyl ether can generate four contiguous stereocenters with a high degree of stereoselectivity in favor of (3S,4S,5R,6R)-2-methyl-5-nitro-4,6-diphenylcyclohex-l-ene carbaldehyde as the final product [46]. More importantly, mechanistic investigations aimed to establish the reasons behind the isolation of only two epimers out of 16 possible stereoisomers. 

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