Measurement limit of detection

Sensitivity is a measure of the smallest concentration that can be either measured [limit of detection (LOD)] or accurately quantitated [limit of quantitation (LOQ)]. In the USA, the method for measuring LOD or LOQ is left up to the method developer. European requirements for determining LOD and LOQ are very specific the LOD is based on the mean plus three standard deviations for 20 control blank samples, and the LOQ is defined as the lowest concentration giving an acceptable CV. 

Synovec and Yeung developed a highly selective and sensitive laser-based CD detector for both conventional and microbore liquid chromatography [30] and applied it to the analysis of complex mixtures of optically active metal complexes. As expected limits of detection are very low. For example for the determination of (+) trisfethylenenediamine) cobalt (HI) using an Ar-ion laser source, a microbore column, and a CD detector operating at 488 nm, the measured limit of detection is 5.6 ng. 

Method Object of measurement Limit of detection Spatial resolution Remarks... 

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