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Me Combie

Cydization of P-hydroxy-a-amino esters under Mitsunobu reaction conditions is an alternative approach to aziridine-2-carboxylic esters [6b, 13-16], In this case the P-hydroxy group is activated by a phosphorus reagent. Treatment of Boc-a-Me-D-Ser-OMe 13 (Scheme 3.5) with triphenylphosphine and diethyl azodicarboxylate (DEAD), for example, gave a-methyl aziridinecarboxylic acid methyl ester 14 in 85% yield [15]. In addition to PPh3/DEAD [13b, 15], several other reagent combi-... [Pg.75]

See other pages where Me Combie is mentioned: [Pg.870]    [Pg.870]    [Pg.1043]    [Pg.914]    [Pg.947]    [Pg.949]    [Pg.952]    [Pg.319]    [Pg.2493]    [Pg.2526]    [Pg.2528]    [Pg.2531]    [Pg.870]    [Pg.870]    [Pg.1043]    [Pg.914]    [Pg.947]    [Pg.949]    [Pg.952]    [Pg.319]    [Pg.2493]    [Pg.2526]    [Pg.2528]    [Pg.2531]    [Pg.454]    [Pg.357]    [Pg.454]   
See also in sourсe #XX -- [ Pg.26 ]

See also in sourсe #XX -- [ Pg.26 ]



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