MCP methylation in adaptation

One of the first steps in revealing the mechanism of adaptation was the finding that CheR-mediated MCP methylation (Section 7.3) and CheB-mediated demethylation (Section 7.2) are involved in adaptation (for a review, see reference [685]). The basis for the linkage between the 

It has been shown in a cell-free system that the CheR-mediated methylation reaction is enhanced by chemoattractants and inhibited by chemorepellents, but the mechanism underlying these effects is not known [369], The outcome of this methylation is an enhancement of CheA autophosphorylation and, thereby, transmission of a clockwise signal [124, 541], Conversely, the demethylation reaction is enhanced by chemorepellents and inhibited by chemoattractants [369]. The outcome of this demethylation is inhibition of CheA autophosphorylation and, thereby, transmission of a counterclockwise signal [124, 541]. In this 

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