Matrix-isolation VCD

Matrix Isolation VCD Spectroscopy for Probing Conformational Landscapes... 

Fig. 23 Spectra of (S)-alaninol. (a) VCD spectrum, neat film (b) VA spectrum, neat film (c) VCD spectrum of a sample in solution in CDC13 (d) VA spectrum of a sample in solution in CDC13 (e) matrix isolation VCD spectrum ( ) matrix isolation-VA spectrum. Copyright Wiley-VCH Verlag GmbH Co. KGaA. Reproduced with permission from [163]...

Besides the continuous improvements of FTIR-VCD instruments described above, some exciting new developments related to VCD measurements have been reported in recent years. These include the developments of matrix isolation FTIR-VCD instruments and of laser based real time VCD spectrometers. These new developments are associated with brand new applications and research directions, such as combining the matrix isolation technique with VCD spectroscopy to probe conformationally flexible chiral molecules and H-bonded chiral molecular complexes, and using femtosecond laser VCD instruments to record time resolved VCD spectra for monitoring fast chemical reactions or folding and unfolding events of peptides and proteins in solution. These will be discussed in more detail in Sects. 4.5 and 4.6. 

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