Master substituent sequencing

If the seed atom is in a ring, the unplaced neighbors are sequenced by means of the master substituent sequencing algorithm (above), and placed at regular intervals within the seed atom s CFS (Algorithm 8). 

Adding the substituents in the correct order is crucial in mastering ciromatic synthesis problems. Examine the two reaction sequences given in Figure 8-4. Both sequences involve the same reagents however, the order is reversed. This shows that the reaction sequence is important. You need to plan ahead in any multistep reaction sequence. 

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