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Mass neuroactive steroids

Purdy RH, Fitzgerald RL, Everhart ET, Mellon SH, Alomary A, Parsons LH. 2004. The analysis of neuroactive steroids by mass spectrometry. Handbook of Neurochemistry and Molecular Neurobiology, 3rd edition. Volume 18 Practical Neurochemistry (Methods). Baker GB, Dunn SMJ, Holt A, editors. New York Kluwer Academic Publishers. [Pg.15]

Neuroactive steroids are comparatively polar compounds that, in most cases, are derivatized by a suitable reagent before being analyzed by GC/MS. It is essential to add functional groups that enhance ionization efficiency, decrease polarity, and increase volatility of the steroid, thus making it more easily detected by GC/MS. Suitable derivatization of neuroactive steroids also results in enhanced sensitivity and specificity of mass spectra. [Pg.180]

Siuzdak G. 2003. The e3q>anding role of mass spectrometry in biotechnology. MCC Press San Diego pp. 182-189. Strohle A, Romeo E, di Michele F, Pasini A, ssouridis A, et al. 2002. GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder. Am J Psychiatry 159 145-147. [Pg.191]

See other pages where Mass neuroactive steroids is mentioned: [Pg.177]    [Pg.178]    [Pg.178]    [Pg.179]    [Pg.179]    [Pg.180]    [Pg.181]    [Pg.182]    [Pg.183]    [Pg.184]    [Pg.185]    [Pg.186]    [Pg.187]    [Pg.188]    [Pg.189]    [Pg.190]    [Pg.191]    [Pg.192]    [Pg.488]    [Pg.490]    [Pg.266]   
See also in sourсe #XX -- [ Pg.178 , Pg.179 , Pg.180 , Pg.181 , Pg.182 , Pg.183 , Pg.184 , Pg.185 , Pg.186 , Pg.187 , Pg.188 , Pg.189 ]



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